Our Providers

Stephen H. Tsang, MD, PhD
  • Laszlo T. Bito Associate Professor of Ophthalmology and Associate Professor of Pathology and Cell Biology
Stephen H. Tsang, <span>MD, PhD</span>

Stephen H. Tsang, M.D, Ph.D. is an internationally recognized clinician and geneticist specializing in the treatment of retinal disorders.

Dr. Tsang graduated from Johns Hopkins University, where he began his medical genetics training under the tutelage of Professor Victor A. McKusick. He received his M.D.-Ph.D. degrees from the NIH-National Institute of General Medical Sciences Medical Scientist Training Program (MSTP) at Columbia University. Dr. Tsang then completed his residency at Jules Stein Eye Institute/UCLA, followed by studies with Professor  Alan C. Bird and Graham Holder on improving the care of individuals with macular degenerations.

Dr. Tsang is a recognized expert in genome surgery in stem cells. Most recently, he has been invited to lecture at the genome surgery workshop during the annual Association for Research in Vision & Ophthalmology (ARVO) 2015 & 2016 Annual Meetings; and as a Moderator for Gene Editing/Rewriting the Genome: Moving from Association to Biology and Therapeutics session during the 65th American Society of Human Genetics (ASHG) Annual Meeting, and a lecturer at 2015 & 2016 CRISPR Revolution conferences at Cold Spring Harbor. 

In his New York State supported stem cell program (N09G-302), he is examining embryonic stem (ES) cells to model and replace diseased human retinal cells. His contributions were recognized by the 2005 Bernard Becker Association of University Professors in Ophthalmology's Research to Prevent Blindness Award. Dr. Tsang also participates in resident teaching and had been the Columbia ophthalmology basic science course director. He is a member of the American Society of Clinical Investigation.

Dr. Tsang is one of a handful of clinicians who can direct the full spectrum of bench-to-bedside research. PI’s research on cGMP-phosphodiesterase (PDE6) is a case in point. PDE6 defects lead to blindness in 72,000 people worldwide. PI generated the world’s first gene-targeted model of retinitis pigmentosa (a PDE6 mutant), and then used these mice to dissect the underlying pathophysiology. These studies led to novel and fundamental discoveries on PDE6 regulation of G-protein-coupled-receptor signaling and, eventually, preclinical testing in the same mice; of the different therapies tested, viral-gene therapy is slated for clinical trials.. Many of his publications are in top rated general interest journals since as Science and Journal of Clinical Investigation, which attests to the broad impact that his work has had.

Board Certifications

  • Ophthalmology

Areas of Expertise

  • Retinal Disorders
  • Eye Genetics
  • Cancer Care
  • Clinical Genetics
  • Adult Genetics
  • Genetic Disorders
  • Genetic Testing
  • Pediatric Genetics
  • Retina Disorder
  • Retina Hole
  • Retinal Bleeding
  • Retina Degeneration
  • Diabetic Retinopathy
  • Retinal Vascular Disorders
  • Vitreoretinal Disorder
  • Unexplained Vision Loss
  • Loss of Vision
  • Retinopathy
  • Marfan's Syndrome
  • Macular Degeneration
  • Retinal Disease
  • Skin Pigmentation Disorder

    Education & Training

  • Columbia University College of Physicians and Surgeons
  • Internship: New York Hospital Queens
  • Residency: UCLA - Jules Stein Eye Institute
  • Fellowship: Moorfields Eye Hospital, London


  • Edward S. Harkness Eye Institute

    635 West 165th Street
    Floor: 5
    New York, NY 10032
    (212) 305-9535
    For new and current patient appointments, call:
    (212) 305-9535
    (212) 342-5293

Insurance Programs

Please contact the provider's office directly to verify that your particular insurance is accepted.

  • Aetna [EPO, HMO, Medicare, NY Signature, POS, PPO, Signature Administrators, Student Health]
  • Amida Care
  • Cigna [EPO, Great West, HMO, POS, PPO]
  • Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]
  • Empire Blue Cross Blue Shield [Blue Priority, EPO, HMO, Medicare (Mediblue), NYP Employee Plan, Pathway (Exchange), POS, PPO]
  • MagnaCare
  • Medicare [Medicare]
  • Multiplan
  • Oxford Health Plans [Freedom, Liberty, Medicare Managed Care]
  • UnitedHealthcare [Columbia University Employee Plan, Compass (Exchange), EPO, HMO, Medicare Managed Care, POS, PPO]

This provider accepts new patients

Appointment Phone Number: (212) 305-9535

Honors & Awards

  • Named Lectureships
  • 2006                      Dr. Isaac Bekhor Lecturer, Doheny Eye Institute
  •                                     at University of Southern California (9/29)
  • 2013                      Dr. Paul Stringer Memorial Lectureship, McMaster University
  • 2013                      Dr. Bradley Straastma Lecturer, Resident Graduation, UCLA
  • 2015                      Dr. Joginder Nath Lecturer, West Virginia U. School of Medicine
  • 2016                      Lecturer, World Science Festival, CRISPR Technologies
  • 1988 – 1989          Alpha Epsilon Delta, National Premedical Honor Society,
    •                             Maryland Alpha (Historian)
  • 1988 – 1989          Dean’s List, The Johns Hopkins University
  • 1989                      Graduate with Departmental Honor
  • 1989                       Recipient of Student Activities Award, The Johns Hopkins University
  • 1989 – 1997          NIH-National Institute of General Medical Sciences Medical Scientist Training Program: MSTP fellowship PHS Grant # T32 GM 073667-14
  • 1995                      ARVO/National Eye Institute Travel Fellowship
  •                                     Grant for the 1995 ARVO meeting
  • 1996                      Dean’s Award for Excellence in Research, Graduate Sch of Arts & Sciences, Columbia U.
  •                               Dr. Alfred Steiner Award for Best Medical Student Research, Columbia U.
  • 1997                      Best Overall Presentation at Eastern Student Research Forum sponsored by American Medical Association and the University of Miami                  
  • 1997                      Travel Grant, European Students’ Conference at the Charité in Berlin
  • 1998                      Edith McKane Award in Ophthalmology, College of Physicians and Surgeons, Columbia U.
  • 1998                      John Lattimer Award in Urology, College of Physicians and Surgeons, Columbia U.
  • 2000                      Jules Stein Eye Institute Research Award
  • 2000                      RPB-Association of University Professors in Ophthalmology (AUPO) Resident Award
  • 2001 – present       Fight for Sight/Grant-In-Aid Review Panel Member
  • 2003                      Burroughs-Wellcome Fund Career Award in Biomedical Sciences
  • 2003                      RPB Association of University Professors in Ophthalmology Resident Award
  • 2003                      Nesburn Resident Award
  • 2004                      Dennis W. Jahnigen Award, American Geriatrics Society
  • 2005                      Becker-AUPO-RPB Award
  • 2006                      ARVO/Alcon Early Career Clinician Scientist Award
  • 2007                      Charles E. Culpeper Award
  • 2008                      Teacher Recognition Award, Columbia U.
  • 2008 – 2009          Listed as one of “America’s Top Ophthalmologists” by Consumers’ Research Council of America http://consumersresearchcncl.org/Healthcare/Ophthalmologists/top_ophth.html
  • 2009                      Patients' Choice Award for 2008
  • 2009                      Elected to Macular Society
  • 2010                      Keynote Speaker, GTCbio 2nd Annual Ocular Diseases
  •                                     & Drug Discovery  conferen. May 28, 2010
  • 2012                      Invited Lecturer, University of Geneva
  • 2013, 14                Elected by his peers for inclusion in Best Doctors in America®
  • 2013                       ARVO Foundation Carl Camras Award
  • 2014                       Foundation Fighting Blindness Visionary Award
  •                                         Recipient and “Banking on a Cure” Honoree
  • 2015                       ARVO 2015 Annual Meeting Gene Editing Symposium
  •                                        Invited Lecturer in Denver, Colorado
  • 2015                       Elected to American Ophthalmological Society
  • 2015                       Invited Lecturer,Deutsche Ophthalmologische Gesellschaft DOG
  • 2015                       Plenary lecture, Rensselaer Center
  •                                    for Stem Cell Research (RCSCR) - Symposium
  • 2015                       Chair,  Gene Editing/Rewriting the Genome Symposium
  •                                        American Society of Human Genetics Annual Meeting
  • 2016                       Elected to American Society for Clinical Investigation