Symptoms: the corneal changes are rarely of any visual significance.
Signs:
Symmetric, bilateral, whorl-like pattern of powdery, white, yellow or brown corneal epithelial deposits
Appears in a vortex fashion in the inferocentral cornea and swirls outwards sparing the limbus
Occurs in Fabry's disease and in patients being treated with a variety of drugs including amiodarone, chloroquine, amodiaquine, meperidine, indomethacin, chlorpromazine and tamoxifen.