Avellino

Avellino (Granular-lattice) Dystrophy 

  • Autosomal dominantly inherited with very high penetrance and moderately variable expressivity.

Clinical features:

  • Symptoms: glare, foreign body sensation, decreased vision or recurrent painful epithelial erosions.
  • Signs:
    • Bilateral, often asymmetric, grey-white well-circumscribed central anterior stromal opacity similar to those seen in granular dystrophy
    • Deep lattice-like stromal deposits
    • Older patients have anterior stromal haze between deposits
    • Family trace study revealed that patients with this dystrophy were from Avellino, Italy

Management:

  • Superficial debridement, lamellar keratoplasty, and excimer laser phototherapeutic keratectomy.
  • Penetrating keratoplasty is indicated for deeper involvement.
  • Recurrence may occur after keratoplasty.