Prominent Corneal Nerve

Prominent corneal nerve in a patient with hereditary ichtyosis. 

  • More commonly associated with Multiple Endocrine Neoplasia (MEN) type II b.
  • Several other systemic disorders where this corneal finding may be found include Refsum's disease, hereditary ichthyosis, neurofibromatosis type I, leprosy and primary amyloidosis.
  • Ocular diseases that may be associated with enlarged corneal nerves are keratoconus, Fuchs' or Reis-Buckler's corneal dystrophy, acanthamoeba keratitis and corneal graft failure.