- Associate Professor of Ophthalmic Sciences (in Ophthalmology & Pathology & Cell Biology)
The primary focus of Dr. Zhang's research is to investigate the mechanism of cell signaling during eye development. Using a genetic approach, he dissects signaling pathways that are not only essential for embryonic development but are also functionally important. Recently, he has broadened his investigations to examine the development of diverse ocular structures, including the retina, optic nerve and lacrimal gland. His long-term goal is to combine mouse genetics with biochemical approaches to determine how intracellular signaling is received and interpreted in eye development and homeostasis.
Dr. Zhang holds an undergraduate degree in Physics from Beijing University and a Ph.D. from Johns Hopkins University. He completed post-doctoral training in genetics at Harvard, where he studied genes, such as PAX6, that are related to ocular development.
Postdoctoral Research Scientists:
Grinu Mathew, PhD
Hongge Li, PhD
- BS, Physics, Beijing University (China)
- PhD, Biology, Johns Hopkins University
Education & Training
Honors & Awards
- David D. Weaver Investigator, Department of Medical and Molecular Genetics, IUSM; 2011 – Present
- Basil O'Connor Scholar, March of Dimes Birth Defects Foundation; 2005 – 2007
- Postdoctoral Training Grant, National Eye Institute; 2001 – 2002
- Beijing University Fellowship, Beijing University, Beijing, China; 1987, 1991
- Cai Z, Tao C, Ladher R, Gotoh N, Feng G, Wang F, Zhang X. 2013. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. Under revision.
- Carbe C, Garg A, Cai Z, Li H, Powers A, Zhang X. 2013. An Allelic Series at the Pax6 Locus Reveals the Functional Specificity of Pax Genes. Journal of Biological Chemistry. Under revision.
- Qu X, Pan Y, Carbe C, Powers A, Grobe K, Zhang X. 2012. Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development. 139, 2730-2739.
- Carbe C, Hertzler-Schaefer K, Zhang X. 2012. The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Developmental Biology. 363(1):320-9.
- Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X. 2011. Loss of Shp2-mediated MAPK signaling in Müller glial cells results in retinal degeneration. Molecular and Cellular Biology. 31:2973-2983.
- Qu X, Hertzler K, Pan Y, Grobe K, Robinson ML, Zhang X. 2011. Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development. Developmental Biology. 355:12–20.
- *Qu X, Carbe C, Tao C, Powers A, Lawrence R, van Kuppevelt TH, Cardoso WV, Grobe K, Esko JD, Zhang X. 2011. Lacrimal gland development and Fgf10-Fgfr2b signaling is controlled by 2-O and 6-O sulfated heparan sulfate. Journal of Biological Chemistry. 286(16):14435-14444. *Rated at the top 2% of published articles in biology and medicine by the Faculty of 1000 (F1000).
- Carbe C and Zhang X. 2011. Lens induction requires attenuation of ERK signaling by Nf1. Human Molecular Genetics. 20(7):1315–1323.
- Cai Z, Feng GS, Zhang X. 2010. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. Journal of Neuroscience. 30(11):4110–4119
- Pan Y, Carbe C, Powers A, Feng GS, Zhang X. 2010. Sprouty2 modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development. 137:1085-1093.
- Lachke SA, Zhang X, Maas RL. 2010. Photoreceptor cell development control. Encyclopedia of Life Sciences. DOI: 10.1002/9780470015902.a0000833.pub2
- Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, Zhu W, Bu G, Jin T, Wang Z, Zhang X, Chen J, Field LJ, Rubart M, Shou W, and Chen Y. 2009. Smad7 is required for the development and function of heart. Journal of Biological Chemistry. 284(1):292-300.
- Pallerla SR, Lawrence R, Lewejohann L, Pan Y, Fischer T, Schlomann U, Zhang X, Esko JD, Grobe K. 2008. Altered heparan sulfate structure in mice with deleted NDST3 gene function. Journal of Biological Chemistry. 283(24):16885–16894.
- Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng GS, Zhang X. 2008. Bud specific N-sulfation of heparan sulfate regulates Shp2 dependent FGF signaling during lacrimal gland induction. Development, 135:301-310.
- Liu Z, Dong Z, Yang Z, Chen Q, Pan Y, Yang Y, Cui P, Zhang X, Zhang JT. 2007. Role of eIF3 p170 (eIF3a) in intestinal cell differentiation and its association with early development. Differentiation 75(7):652-661.
- Pallerla SR, Pan Y, Zhang X, Esko JD, Grobe K. 2007. Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. Developmental Dynamics 236(2):556-563.
- Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL. 2006. Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Developmental Biology 300:748–757.
- Pan Y, Woodbury A, Esko JD, Grobe K, Zhang X. 2006. Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development 133:4933-4944.
- Zhang X, Heaney S, Maas RL. 2003. Cre-loxP fate mapping of Pax6 enhancer active retinal and pancreatic progenitors. Genesis 35(1):22-30.
- *Zhang X, Friedman A, Purcell P, Heaney S, Maas RL. 2002. Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes & Development 16(16):2097-2107.
- Zhang X, Maas RL. 2002. Photoreceptor cell development control. Encyclopedia of Life Sciences 14:228-233. London: Nature Publishing Group. [http://www.els.net]
- Xu P, Zhang X, Heaney S, Yoon A, Michelson A, Maas R. 1999. Regulation of Pax6 expression is conserved between mice and flies. Development 126:383-395.
- Zhang X, Schleif R. 1998. Catabolite gene activator protein mutations affecting activity of the araBAD promoter. Journal of Bacteriology 180(2):195-200.
- Zhang X, Schleif R. 1996. Obligatory activator-polymerase addition order at promoters. Nucleic Acids Research 24(13):2575-2577.
- Zhang X, Reeder T, Schleif R. 1996. Transcription activation parameters at ara pBAD. Journal of Molecular Biology 258:14-24.
- Gao Q, Yuan H, Zhang X, Fen X, Li J, Yang Y, Lin Z, Pen X, Lu F. 1992. A study of interface structure between diamond film and silicon substrate. Thin Solid Films 221:34-38.
- Chen C, Qu M, Hu W, Zhang X, Lin F, Hu H, Ma K, Giriat W. 1991. Magnetization and magnetic susceptibility of diluted magnetic semiconductor Cd1-x MnxS. Journal of Applied Physics 69(8):6114-6116.